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and though this alteration proves sometimes unfortunate, yet many times most happy: but its possible by others faults, wise men may correct their errors, and give those testimonies of fidelity, which may occasion a mutuall antity, which cannot be expected, till this burthen be eased, and the sicknesse cured

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HACE1 reduces oxidative stress and mutant huntingtin toxicity by promoting the NRF2 response